GCLC
gene productGCS, GLCL, GLCLC
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. [provided by RefSeq, Oct 2010]
Featured antibodies
 Atlas Antibodies |
 HPA036360 |
0 references | Polyclonal |
WB
ICC
IHC
|
 Biorbyt |
orb29915 |
0 references | Polyclonal |
WB
EL 
ICC
IHC
FC
|
Antibodies
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Enhanced validation Enhanced validation
Supportive data in Antibodypedia
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Validated within AVI
Eligible for validation within AVI