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OTX2
Orthodenticle homeobox 2This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]
Top validated antibodies |
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| Invitrogen Antibodies |  MA5-15854 |
5 references | Monoclonal |
WB
EL
ICC
IHC
FC
OA
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| antibodies-online | ABIN969332 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Proteintech Group | 13497-1-AP |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| R&D Systems | AF1979 |
28 references | Polyclonal |
WB
ICC
IHC
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| Acris Antibodies GmbH | AM06629SU-N |
Monoclonal |
WB
EL
ICC
IHC
FC
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