CX3CR1

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Description

C-X3-C motif chemokine receptor 1

Protein family

Disease related genes, G-protein coupled receptors, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential drug targets, Predicted membrane proteins, Protein evidence (Peptideatlas)

Chromosome

3:p22.2 (39263494 - 39281735)

Ensembl ID

ENSG00000168329  (ver. 99.38)

Orthologs

Mouse Cx3cr1: ENSMUSG00000052336

UniProt

P49238

neXtProt

NX_P49238

Human splice variants
Mouse splice variants