FGB

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]

Description

Fibrinogen beta chain

Tissue specificity

Tissue enriched (liver)

Subcell location

Endoplasmic reticulum

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (154563011 - 154572807)

Ensembl ID

ENSG00000171564  (ver. 103.38)

Orthologs

Mouse Fgb: ENSMUSG00000033831

UniProt

P02675

neXtProt

NX_P02675

Human splice variants
Mouse splice variants

Protein structure