UPF1

gene product
HUPF1, KIAA0221, NORF1, pNORF1, RENT1, smg-2
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Validated by best practice
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
212 antibodies from 28 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
Bethyl Laboratories, Inc.
10 antibodies
OriGene
4 antibodies
Atlas Antibodies
2 antibodies
Novus Biologicals
9 antibodies
NovoPro Bioscience Inc.
1 antibody
Proteintech Group
1 antibody
Bioworld Technology, Inc
1 antibody
antibodies-online
56 antibodies
LifeSpan BioSciences, Inc.
22 antibodies
GeneTex
5 antibodies
Aviva Systems Biology
3 antibodies
Cell Signaling Technology, Inc
2 antibodies
Abnova Corporation
3 antibodies
Invitrogen Antibodies
2 antibodies
NSJ Bioreagents
1 antibody
RabMAbs
4 antibodies
Creative Diagnostics
4 antibodies
Acris Antibodies GmbH
4 antibodies
Biorbyt
10 antibodies
Abgent
1 antibody
R&D Systems
1 antibody
United States Biological
38 antibodies
St John's Laboratory
2 antibodies
MyBioSource
3 antibodies
EMD Millipore
5 antibodies
Sigma-Aldrich
3 antibodies
GenWay
3 antibodies