Tissue expression
Cell line expression
Protein structure
HDAC1
Histone deacetylase 1GON-10, HD1, KDAC1, RPD3L1
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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GeneTex | ![]() |
13 references | Polyclonal |
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Proteintech Group | ![]() |
96 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
68 references | Polyclonal |
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Novus Biologicals | ![]() |
1 references | Monoclonal |
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Abnova Corporation | ![]() |
1 references | Monoclonal |
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