Tissue expression
Cell line expression

CD19

gene product
 
This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]
More gene data

Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Antigen sequence

Conjugate

Epitope

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
5111 antibodies from 55 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
OriGene
148 antibodies
Novus Biologicals
439 antibodies
antibodies-online
1333 antibodies
NSJ Bioreagents
14 antibodies
GeneTex
42 antibodies
Proteintech Group
19 antibodies
Abgent
6 antibodies
Invitrogen Antibodies
287 antibodies
Cusabio Biotech Co., Ltd
15 antibodies
NovoPro Bioscience Inc.
6 antibodies
LifeSpan BioSciences, Inc.
538 antibodies
Biorbyt
168 antibodies
Affinity Biosciences
5 antibodies
Cell Signaling Technology, Inc
18 antibodies
ProSci
35 antibodies
BioLegend
119 antibodies
Abnova Corporation
72 antibodies
R&D Systems
24 antibodies
Boster Biological Technology
17 antibodies
Antibodies.com
18 antibodies
HUABIO Research
4 antibodies
Acris Antibodies GmbH
106 antibodies
Bethyl Laboratories
2 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
ABEOMICS Inc.
7 antibodies
Aviva Systems Biology
39 antibodies
Santa Cruz Biotechnology
1 antibody
Abbkine Scientific Co.Ltd.
3 antibodies
Bioworld Technology, Inc
3 antibodies
St John's Laboratory
12 antibodies
RabMAbs
2 antibodies
Creative Biolabs
887 antibodies
Absolute Antibody
29 antibodies
Everest Biotech
1 antibody
Creative Diagnostics
40 antibodies
Sino Biological Inc.
5 antibodies
SICGEN
2 antibodies
GenWay
65 antibodies
Leading Biology
13 antibodies
FabGennix
3 antibodies
Miltenyi Biotec
104 antibodies
STEMCELL Technologies Inc
42 antibodies
Spring Bioscience
8 antibodies
Abbiotec
9 antibodies
Abbexa
61 antibodies
MyBioSource
21 antibodies
MilliporeSigma / Merck KGaA
14 antibodies
EMD Millipore
9 antibodies
Rockland Immunochemicals, Inc.
9 antibodies
United States Biological
83 antibodies
eBioscience, An Affymetrix Company
82 antibodies
RayBiotech, Inc.
1 antibody
Exalpha Biologicals, Inc.
13 antibodies