SPHK1

gene product
SPHK
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
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715 antibodies from 44 providers.

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R&D Systems
3 antibodies
Novus Biologicals
49 antibodies
Proteintech Group
2 antibodies
GeneTex
8 antibodies
Invitrogen Antibodies
20 antibodies
antibodies-online
227 antibodies
Abgent
10 antibodies
Abnova Corporation
16 antibodies
Biorbyt
26 antibodies
Aviva Systems Biology
8 antibodies
LifeSpan BioSciences, Inc.
106 antibodies
NSJ Bioreagents
6 antibodies
OriGene
19 antibodies
Boster Biological Technology
2 antibodies
Bioworld Technology, Inc
1 antibody
NovoPro Bioscience Inc.
10 antibodies
ProSci
6 antibodies
Affinity Biosciences
2 antibodies
Antibodies.com
1 antibody
Arigo
4 antibodies
Acris Antibodies GmbH
21 antibodies
Atlas Antibodies
2 antibodies
St John's Laboratory
4 antibodies
Everest Biotech
2 antibodies
FabGennix
3 antibodies
Bethyl Laboratories
2 antibodies
Cell Signaling Technology, Inc
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
RabMAbs
5 antibodies
BioLegend
1 antibody
United States Biological
74 antibodies
Creative Biolabs
11 antibodies
MyBioSource
14 antibodies
Creative Diagnostics
5 antibodies
Abiocode, Inc.
1 antibody
Leading Biology
8 antibodies
Sigma-Aldrich
7 antibodies
Abbiotec
1 antibody
EMD Millipore
1 antibody
Exalpha Biologicals, Inc.
1 antibody
Abbexa
3 antibodies
RayBiotech, Inc.
3 antibodies
GenWay
1 antibody