Tissue expression
Cell line expression

PTEN

gene product
BZS, MHAM, MMAC1, PTEN1, TEP1 
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
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1820 antibodies from 53 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
7 antibodies
Invitrogen Antibodies
33 antibodies
Novus Biologicals
23 antibodies
R&D Systems
11 antibodies
GeneTex
25 antibodies
Enzo Life Sciences
1 antibody
Abgent
25 antibodies
LifeSpan BioSciences, Inc.
553 antibodies
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St John's Laboratory
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Biorbyt
157 antibodies
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Signalway Antibody LLC
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Affinity Biosciences
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Wuhan Fine Biotech Co., Ltd.
3 antibodies
Boster Biological Technology
15 antibodies
Bioworld Technology, Inc
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ProSci
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Antibodies.com
1 antibody
ABEOMICS Inc.
2 antibodies
Atlas Antibodies
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Abbkine Scientific Co.Ltd.
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RabMAbs
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Abbiotec
3 antibodies
SignalChem
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QED Bioscience
1 antibody
antibodies-online
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EMD Millipore
8 antibodies
Abbexa
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MilliporeSigma / Merck KGaA
10 antibodies
Arigo
1 antibody
BioLegend
1 antibody
United States Biological
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Leading Biology
27 antibodies
Miltenyi Biotec
4 antibodies
Creative Diagnostics
14 antibodies
Creative Biolabs
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RayBiotech, Inc.
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MyBioSource
2 antibodies
Abiocode, Inc.
1 antibody
Aviva Systems Biology
1 antibody
GenWay
7 antibodies
Everest Biotech
1 antibody
CPTAC
8 antibodies
Rockland Immunochemicals, Inc.
1 antibody