SMAD1

gene product
JV4-1, MADH1, MADR1
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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1190 antibodies from 37 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
418 antibodies
Abnova Corporation
22 antibodies
Invitrogen Antibodies
9 antibodies
Novus Biologicals
32 antibodies
Proteintech Group
1 antibody
Cell Signaling Technology, Inc
7 antibodies
Biorbyt
89 antibodies
Boster Biological Technology
9 antibodies
Acris Antibodies GmbH
16 antibodies
NovoPro Bioscience Inc.
17 antibodies
Abgent
12 antibodies
OriGene
46 antibodies
NSJ Bioreagents
10 antibodies
GeneTex
10 antibodies
R&D Systems
1 antibody
Santa Cruz Biotechnology
1 antibody
LifeSpan BioSciences, Inc.
163 antibodies