MYD88

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Description

MYD88 innate immune signal transduction adaptor

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Mitochondria, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

3 (38138478 - 38143022)

Ensembl ID

ENSG00000172936  (ver. 103.38)

Orthologs

Mouse Myd88: ENSMUSG00000032508

UniProt

Q99836

neXtProt

NX_Q99836

Human splice variants
Mouse splice variants

Protein structure