CASP8

gene product
Casp-8, FLICE, MACH, MCH5
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
1410 antibodies from 46 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
43 antibodies
antibodies-online
462 antibodies
Enzo Life Sciences
5 antibodies
GeneTex
24 antibodies
Biorbyt
73 antibodies
Aviva Systems Biology
11 antibodies
Proteintech Group
2 antibodies
OriGene
32 antibodies
Abnova Corporation
22 antibodies
Acris Antibodies GmbH
38 antibodies
Abgent
14 antibodies
Invitrogen Antibodies
24 antibodies
NovoPro Bioscience Inc.
3 antibodies
Boster Biological Technology
10 antibodies
LifeSpan BioSciences, Inc.
267 antibodies
Affinity Biosciences
5 antibodies
Cell Signaling Technology, Inc
9 antibodies
ABEOMICS Inc.
3 antibodies
NSJ Bioreagents
7 antibodies
Atlas Antibodies
3 antibodies
R&D Systems
4 antibodies
Signalway Antibody LLC
2 antibodies
St John's Laboratory
12 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
ProSci
7 antibodies
BioLegend
3 antibodies
Bioworld Technology, Inc
5 antibodies
Abbkine Scientific Co.Ltd.
7 antibodies
Abbexa
5 antibodies
RabMAbs
7 antibodies
Creative Biolabs
68 antibodies
Creative Diagnostics
16 antibodies
Arigo
6 antibodies
MyBioSource
27 antibodies
EMD Millipore
6 antibodies
United States Biological
110 antibodies
Spring Bioscience
4 antibodies
Abbiotec
2 antibodies
RayBiotech, Inc.
11 antibodies
GenWay
9 antibodies
Abiocode, Inc.
1 antibody
Active Motif
1 antibody
Sigma-Aldrich
8 antibodies
eBioscience, An Affymetrix Company
3 antibodies
Exalpha Biologicals, Inc.
2 antibodies