ROCK2

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

Description

Rho associated coiled-coil containing protein kinase 2

Protein family

Enzymes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

2:p25.1 (11179759 - 11348330)

Ensembl ID

ENSG00000134318  (ver. 99.38)

Orthologs

Mouse Rock2: ENSMUSG00000020580

UniProt

O75116

neXtProt

NX_O75116

Human splice variants
Mouse splice variants