MMP2

gene product
CLG4, CLG4A, TBE-1
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
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1484 antibodies from 46 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
17 antibodies
antibodies-online
526 antibodies
Invitrogen Antibodies
17 antibodies
R&D Systems
18 antibodies
Novus Biologicals
102 antibodies
Biorbyt
81 antibodies
Abnova Corporation
20 antibodies
Arigo
7 antibodies
Acris Antibodies GmbH
24 antibodies
NovoPro Bioscience Inc.
6 antibodies