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Protein structure
ERBB4
Erb-b2 receptor tyrosine kinase 4ALS19, HER4
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies |  MA1-861 |
33 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA
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| Proteintech Group | 19943-1-AP |
15 references | Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NB100-2662 |
2 references | Monoclonal |
WB
ICC
IP
IHC
FC
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| GeneTex | GTX111276 |
1 references | Polyclonal |
WB
ICC
IP
IHC
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| LSBio | LS-C199055 |
Polyclonal |
WB
EL
ICC
IHC
|
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