ERBB4

gene product
ALS19, HER4
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
22 antibodies
Novus Biologicals
61 antibodies
GeneTex
13 antibodies
antibodies-online
460 antibodies
R&D Systems
14 antibodies
Biorbyt
77 antibodies
Abgent
14 antibodies
Abnova Corporation
11 antibodies
Affinity Biosciences
6 antibodies
LifeSpan BioSciences, Inc.
284 antibodies